Cancer Center Research

Molecular Signatures and Cancer Therapuetics Research Program
Program Leader: Thomas Kieber-Emmons, PhD

Molecular Signatures Program: Goals and Objectives
The primary mission of this program is to improve cancer diagnosis and therapy by defining distinguishing molecular signatures of tumor cells, determining frequencies and levels of expression of known tumor antigens in targeted malignancies, and developing investigator-initiated clinical trials involving immunotherapy against novel tumor antigens present on prostate, ovarian, cervical, breast or myeloma tumor cells.

Molecular Signatures Program: Significance to the Field of Cancer
Defining the molecular signatures or genes, proteins, and other molecular features associated with cell types will enable physicians to diagnosis cancers early and improve the specificity of cancer diagnosis by evaluating tumor differentiation at the molecular level. Such knowledge will also enable physicians to characterize tumors more efficiently, compose highly effective treatments tailored to the features of each case, and finally, effectively monitor each cancer patient’s recovery or potential tumor recurrence. Significant promise lies in the development of immune-based therapies for cancer and is a focus of several investigators in the program. Development of specific vaccines is one therapeutic option for cancers that have failed all other treatment regimens.

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